Cutaneous Lymphoma and Tumormicroenvironment

Prof. Dr. med. Christina Mitteldorf

  • Cutaneous lymphomas: Improvement of diagnostic methods for early tumor detection and lymphoma classification. Systematic and standardized evaluation of checkpoint and targeted molecules.
  • Cutaneous Pseudolymphomas: We investigate human samples by histology, immunohistochemistry and molecular diagnostics to find discriminating factors from cutaneous lymphomas.
  • Tumormicroenvironment and PD1 and PD-L1 expression in cutaneous neoplasms: We use immunohistochemical and immunofluorescence multi stains to characterize the composition of the TME and to image relations between different cell types. One intention is to localize targeted molecules (e.g. PD-L1) on different cell types.
  • Digital image analysis: We use digital image analysis to evaluate the expression of surface proteins.    
  • Development of a digital learning platform for dermatopathology

Cutaneous lymphomas:

Immunohistochemical and immunofluorescence multi stain in primary cutaneous diffuse large B-cell lymphoma. Nuclear brown (IHC) / red (IF): PAX-5 and membraneous red (IHC) / green (IF): PD-L1; from: Mitteldorf et al. Tumor Microenvironment and Checkpoint Molecules in Primary Cutaneous Diffuse Large B-Cell Lymphoma-New Therapeutic Targets. Am J Surg Pathol 2017 Jul;41(7):998-1004
Immunohistochemical and immunofluorescence multi stain in primary cutaneous diffuse large B-cell lymphoma. Nuclear brown (IHC) / red (IF): PAX-5 and membraneous red (IHC) / green (IF): PD-L1; from: Mitteldorf et al. Tumor Microenvironment and Checkpoint Molecules in Primary Cutaneous Diffuse Large B-Cell Lymphoma-New Therapeutic Targets. Am J Surg Pathol 2017 Jul;41(7):998-1004

Tumormicroenvironment and PD1 and PD-L1 expression in cutaneous neoplasms:

Merkel cell carcinoma: Immunohistochemical double stains for merkel cell polyoma virus (MCPyV, red) and PD-L1 (brown). From Mitteldorf C et al. PD-1 and PD-L1 in neoplastic cells and the tumor microenvironment of Merkel cell carcinoma et al. J Cutan Pathol. 2017 Sep;44(9):740-746.
Merkel cell carcinoma: Immunohistochemical double stains for merkel cell polyoma virus (MCPyV, red) and PD-L1 (brown). From Mitteldorf C et al. PD-1 and PD-L1 in neoplastic cells and the tumor microenvironment of Merkel cell carcinoma et al. J Cutan Pathol. 2017 Sep;44(9):740-746.

Team

  • Viktoria Amon
  • Dr. Johanna Hoffmann
  • Noman Langer
  • Franziska Kampa
  • Aleksandra Kulberg
  • Nikola Rapsch

Contact

Oberärztin

Prof. Dr. med. Christina Mitteldorf

Kontaktinformationen

    • Oberärztin / Fachärztin für Dermatologie und Venerologie, Medikamentöse Tumortherapie, Dermatohistologie
    • International Board Certification in Dermatopathology
    • Oberärztliche Leitung der Dermatohistologie und der Lymphomsprechstunde
    • Pubmed-Link

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