Experimental Allergology and Immunology
Dr. rer. nat. Andrea Braun
Epidermal barrier dysfunction and the development of allergic diseases
The loss of skin barrier proteins such as Filaggrin (Flg) and hornerin (Hrnr) appears to not only cause primary skin barrier defects (Figure 1), but also constitutes a risk factor for allergic disorders, especially atopic dermatitis (AD), but also eczema-related asthma. This stepwise development of atopic disease is a process described as ‘atopic march’ (Figure 2).
Our research focus is to understand how impaired skin barrier function impacts the development of cutaneous inflammation, e.g. atopic dermatitis and the further establishment of atopic diseases in an experimental model.
- Development of a mouse model with skin barrier impairment: FlgHrnr-/- mice, reflecting the subclinical phenotype seen in humans and therefore are of clinical relevance (Rahrig et al. 2019, Thyssen et al. 2020).
- Study the pathomechansims of skin barrier impairment and the susceptibility to develop cutaneous inflammation (Rahrig et al. 2019).
- Implementation of a model for experimental atopic march to study the effect of skin inflammation during AD onto antigen-sensitization and the induction of asthmatic features in skin barrier-impaired FlgHrnr-/- mice.
- Elucidate the mechanisms underlying the immunological process leading from the skin to the lung.
- Andrea Braun, Group Leader
- Caroline Breysach, Technical Assistent
- Sarah Gründemann, Medical Student
- Annette Bennemann, Technical Assistent
- Dr. med. Birka Brauns, Medical Fellow
- Dr. med. Fiona Brunnert, Medical Student
- Dr. med. Judith Dettman, Medical Student
- Franziska Fries, Master Molecular Medicine
- Dr. med. Jan-Hendrik Hardenberg, Medical Student
- Dr. med. Kristina Kotzerke, Medical Student
- Dr. med. Sebastian Rahrig, Medical Student
- Konstantin Reier, Medical Student
- Laura Rekowski, Master Molecular Medicine
- Benjamin Sahlke, Technical Assistent
- Emilia Schmid, Medical Student
- Dr. med. Viktor Schnabel, Medical Fellow
- Ulla Unkelbach, Technical Assistent